Safely Harnessing the Immune System to Conquer Cancer
Amunix is leveraging our expertise in precision protein engineering to enable the promise of T cell engagers in solid tumors. Our goal is to save cancer patients’ lives through the development and commercialization of breakthrough therapies that harness the immune system. We have invented XTEN, a validated therapeutic half-life extension technology. Our current focus is Pro-XTEN, a next-generation protease activated pro-drug platform, which enables selective activation of potent cancer therapies in the tumor microenvironment. This overcomes a common challenge facing potent immune system activators: on-target, off-tumor toxicity. Amunix’s two lead programs employ the Pro-XTEN technology to enhance the safety profile of T cell engagers. XPATs (XTENylated Protease-Activated T Cell Engagers) have the potential to make off-the-shelf therapies redirecting T cells to solid tumors a reality.
Amunix’s robust technology has been validated through multiple collaborations with leading biopharmaceutical companies including Celgene, Genentech, Janssen, Roche, and Bioverativ (now Sanofi). In addition, XTENylated drugs have been dosed in greater than 200 patients with minimal immunogenicity against XTEN.