Mika Derynck, M.D.
Chief Medical Officer
Dr. Derynck is the Chief Medical Officer of Amunix. She is an accomplished drug developer with over 25 years of experience in cancer research, including a 15-year career at Genentech/Roche. She has deep expertise in oncology drug development, which spans multiple therapeutic modalities, tumor types, and all phases of development. During her tenure at Genentech/Roche, she oversaw the approvals and/or global development for over a dozen drugs, including Perjeta®, Avastin®, Tecentriq®, Cotellic®, ipatasertib, taselisib, pictilisib, and apitolisib. Most recently, she served as the Global Head for Cancer Immunotherapy, GI/GU Cancers, Angiogenesis Franchises and China Oncology Development. She also served as the Co-Chair of the Cancer Immunotherapy Committee (CITC), the GI/GU Franchises Committee, and the Breast Cancer Disease Area Team. Dr. Derynck was also a Senior Group Medical Director of Exploratory Clinical Development at Genentech, serving as the development lead for multiple early-stage programs. Before Genentech, Dr. Derynck was an Assistant Clinical Professor in the UCSF Department of Cellular and Molecular Pharmacology and Division of Hematology / Oncology. Dr. Derynck holds a B.A. from Boston University and an M.D. from Boston University School of Medicine. She completed an internal medicine residency at Johns Hopkins, followed by a fellowship in Hematology / Oncology at UCSF and a postdoctoral fellowship at UCSF.
Maninder Hora, Ph.D.
Chief Technical Operations Officer
Dr. Maninder Hora currently serves as the Chief Technical Operations Officer of Amunix. Dr. Hora has served the biopharmaceutical industry for more than 30 years with demonstrated leadership in process, analytical and pharmaceutical sciences, manufacturing and quality functions. He has been part of teams that have successfully filed 50+ INDs and registered 11 biopharmaceutical products worldwide. Prior to joining Amunix, he served as the Chief Technical Operations Officer of Nektar Therapeutics, where he spearheaded strategic direction and execution of all process and product development as well as manufacturing activities. Prior to Nektar, he served as Vice President of Product Operations & Quality at Facet Biotech/ PDL BioPharma (now a part of Abbvie) and Vice President of Process and Product Development at Chiron Corporation (now Novartis). Prior to that, he held positions of increasing responsibilities at Chiron, Pfizer and GSK.
Dr. Hora received his Ph.D. from the Indian Institute of Technology in Bioengineering (Materials) in 1980 and held a Fulbright fellowship at the University of Washington, Seattle. He holds 23 US Patents and has authored scores of publications and delivered numerous presentations in international forums. He serves on the Scientific Advisory Board for Cristal Therapeutics, an emerging nanotechnology-based biopharmaceutical company.
Bryan Irving, Ph.D.
Chief Scientific Officer
Dr. Bryan Irving currently serves as the Chief Scientific Officer of Amunix. He has 30 years of experience in immunology, with nearly 20 years in industry focused on discovering and progressing immune drug candidates into the clinic for both autoimmune and oncology indications. Prior to joining Amunix, he served as Chief Scientific Officer of Five Prime Therapeutics, where he led research and preclinical drug development, and as Vice President of Cancer Immunology at CytomX Therapeutics, where he led immune applications of their protease-activatable, prodrug technology (included T cell bispecifics and T cell checkpoint targets). Prior to CytomX, he worked 12 years as a scientist at Genentech in the Departments of Immunology and Oncology/Cancer Immunology, where he was a key inventor and research leader for the PD-L1 immunotherapy atezolizumab (Tecentriq).
Dr. Irving received his Ph.D in Immunology from the University of California, San Francisco, and a B.A. in Physiology from the University of California, Berkeley. His doctoral work, performed in the laboratory of Dr. Arthur Weiss, pioneered the single-chain chimeric antigen receptor (CAR) technology. He performed post-doctoral work at Harvard and UCSF on early T cell development. His work has been published in top tier journals including Cell, Science, Cancer Cell, Nature Immunology, and Immunity, and he is an inventor on patents that include the single-chain CARs and atezolizumab. Dr Irving is also a musician and studied clarinet performance at the Eastman School of Music at the University of Rochester, NY.
Darcy Mootz, Ph.D.
Chief Business Officer
Dr. Mootz is the Chief Business Officer of Amunix. Before joining the company, she was an independent consultant working with VCs and pharmaceutical companies on a wide range of corporate development and strategy projects. Prior to that, she served as Chief Business Officer of ORIC Pharmaceuticals, a private oncology company, where she had a broad operational role. While VP of Corporate Development at Achaogen, she helped the company complete a successful IPO, led the project team for the company’s lead Phase 3 antibiotic (now launched as ZEMDRI), and helped raise over $100M in non-dilutive capital. Earlier experiences include playing key roles in a successful M&A while at BiPar Sciences, and in a successful new indication launch for Avastin while at Genentech.
Dr. Mootz started her career in industry at L.E.K. Consulting. She earned a B.S. in Biology from Duke University and a Ph.D. in Biochemistry from Harvard University.
Volker Schellenberger, Ph.D.
President and Chief Technology Officer
Dr. Volker Schellenberger is a co-founder of Amunix and currently serves as President and Chief Technology Officer. Dr. Schellenberger has extensive industry experience in protein engineering and drug discovery. Previously, he headed the Protein Engineering department at Genencor, where he invented combinatorial consensus mutagenesis, selection by micro-compartmentalization, as well as mutator technology. In addition, he initiated and led collaborations with Seattle Genetics that focused on antibody-enzyme fusion proteins. Prior to his work on biotherapeutics, Dr. Schellenberger directed projects optimizing enzymes for industrial applications as well as microbes for metabolic pathway engineering.
Dr. Schellenberger received his Ph.D. from Leipzig University, where he studied protease catalyzed peptide synthesis. After postdoctoral studies at the Institute for Protein Research in Pushchino (Russia), he moved to the University of Göttingen where he developed a novel method for the production of peptides from recombinant peptide-multimers. After a postdoctoral fellowship with Bill Rutter at the University of California, San Francisco, Dr. Schellenberger joined Genencor in 1994. Dr. Schellenberger is the author of over 40 scientific papers and an inventor on more than 70 issued and pending patent applications. He is also the recipient of the Karl Lohman award of the German Society of Biochemists.
Angie You, Ph.D.
Chief Executive Officer
Angie serves as Chief Executive Officer of Amunix Pharmaceuticals Inc. Prior to joining Amunix, Dr. You served as Chief Business & Strategy Officer and Head of Commercial at Sierra Oncology (NASDAQ: SRRA), a publicly listed hematology and oncology drug development company, where she helped the company through a successful initial public offering. She also led the company’s strategic and transactional business and commercial efforts, including building its robust pipeline through acquisition and licensing of several product assets. Prior to Sierra, Dr. You served as Chief Business Officer of Aragon Pharmaceuticals, a private oncology drug discovery and development company, where she was responsible for finance, operations, human resources, and business development. At Aragon, Dr. You helped secure several rounds of financing as well as leading the business development process that resulted in the company’s acquisition by Johnson & Johnson. In previous roles, Dr. You served as Chief Business Officer at Synosia Therapeutics and Ren Pharmaceuticals. Before joining Ren Pharmaceuticals, Dr. You focused on new company formation at Venrock Ventures.
Dr. You earned a Ph.D. in Biochemistry from Harvard University and a B.A. in Chemistry from Harvard College.